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Moonlighting Role of Meiotic SYCP1 in Breast Cancer: A Chromatin-Bound Regulator of DNA Repair, Transcription, and Drug Resistance

2025-09-21

Abstract excerpt

Maintenance of genome integrity is essential for cellular homeostasis, and its perturbation leads to tumorigenesis. Here, we uncover an unanticipated somatic role for the synaptonemal complex protein SYCP1—previously regarded as strictly meiosis-specific—in a broad spectrum of human cancers including breast cancer. Through integrative genomic, proteomic, and functional analyses, we demonstrate that SYCP1 is aberra...

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Literature Corpus work
fa26557d-54a8-5b04-ad9f-40c6a156e80c
DOI
10.1101/2025.09.18.677087
Open publication

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Moonlighting Role of Meiotic SYCP1 in Breast Cancer: A Chromatin-Bound Regulator of DNA Repair, Transcription, and Drug ResistanceDOI 10.1101/2025.09.18.677087
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