Article

CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin

2022-12-23

Abstract excerpt

<h4>ABSTRACT</h4> The cohesin complex regulates higher order chromosome architecture through maintaining sister chromatid cohesion and folding chromatin by active DNA loop extrusion. Impaired cohesin function underlies a heterogeneous group of genetic syndromes and is associated with cancer. Here, by using synthetic lethality CRISPR screens in isogenic human cell lines defective of specific cohesion regulators, w...

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Literature Corpus work: afccd2e9-8e8b-5efa-91ac-21adc490074c
DOI: 10.1101/2022.12.23.521474

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