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Article

CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair

1 Aug 2022

Abstract excerpt

A critical determinant of DNA repair pathway choice is REV7, an adaptor that binds to various DNA repair proteins through its C-terminal seatbelt domain. The REV7 seatbelt binds to either REV3, activating translesion synthesis, or to SHLD3, activating non-homologous end joining (NHEJ) repair. Recent studies have identified another REV7 seatbelt-binding protein, CHAMP1 (chromosome alignment-maintaining...

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CRISPR and Genetic Engineering
DNA Repair Mechanisms
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36044844
DOI: 10.1016/j.celrep.2022.111297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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