Article

Co-Essentiality Analysis Identifies PRR12 as a Regulator of Cohesin and Genome Integrity

2024-03-30

Abstract excerpt

<h4>Summary</h4> The cohesin complex is critical for genome regulation, relying on specialized co-factors to mediate its diverse functional activities. Here, by analyzing patterns of similar gene requirements across cell lines, we identify PRR12 as a regulator of cohesin and genome integrity. We show that PRR12 interacts with cohesin and PRR12 loss results in a reduction of nuclear-localized cohesin and an accumu...

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Literature Corpus work: 5fc95925-6f3c-586e-b0d5-3e1f77b38a6c
DOI: 10.1101/2024.03.29.587394

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