Article

Unique molecular features and cellular responses differentiate two populations of motor cortical layer 5b neurons in a preclinical model of ALS

2021-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), lead to the selective degeneration of discrete cell types in the CNS despite the ubiquitous expression of many genes linked to disease. Therapeutic advancement depends on understanding unique cellular adaptations that underlie pathology of vulnerable cells in the context of disease-causing mutations. Here, we employ ba...

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Literature Corpus work: 96984472-e2f4-5815-b744-983a0eb9f444
DOI: 10.1101/2021.05.20.445032

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