Article

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations

2024-03-17

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons that innervate skeletal muscles. However, certain motor neuron groups including ocular motor neurons, are relatively resilient. To reveal key drivers of resilience versus vulnerability in ALS, we investigate the transcriptional dynamics of four distinct motor neuron populations in SOD1G93A ALS mice using LCM-seq and singl...

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Literature Corpus work: f77b8ac8-e010-5561-b785-9477f94e6123
DOI: 10.1101/2024.03.15.584775

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