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Article

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations.

Genome research - 2 Sept 2025

Mei Irene, Nichterwitz Susanne, Leboeuf Melanie, Nijssen Jik, Lenoel Isadora, Repsilber Dirk, Lobsiger Christian S, Hedlund Eva

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons (MNs) that innervate skeletal muscles. However, certain MN groups including ocular MNs, are relatively resilient. To reveal key drivers of resilience versus vulnerability in ALS, we investigate the transcriptional dynamics of four distinct MN populations in SOD1G93A ALS mice using LCM-seq and single-molecule fluorescent...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 40675818
DOI: 10.1101/gr.279501.124
PMCID: PMC12400948

Genes

SOD1
INA
PENK
VGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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