Article

Single-cell profiling of the human primary motor cortex in ALS and FTLD

2021-07-07

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two devastating and fatal neurodegenerative conditions. While distinct, they share many clinical, genetic, and pathological characteristics 1 , and both show selective vulnerability of layer 5b extratelencephalic-projecting cortical populations, including Betz cells in ALS 2,3 and von Economo neurons (VENs) in FTLD 4,5 . Here,...

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Literature Corpus work: 885f3e68-eed9-5505-b9df-3cc02adc1e64
DOI: 10.1101/2021.07.07.451374

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