Article

A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALS

2026-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease characterized by the loss of upper motor neurons in the motor cortex (MTC) and lower motor neurons in the spinal cord, leading to muscle atrophy and ultimately respiratory failure. While motor neurons (MNs) are the selectively vulnerable cell type, their interactions with glia contribute to the progression of ALS pat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31774b78-df10-5fd5-82f7-a976645b3621
DOI: 10.64898/2026.07.24.740361

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALSDOI 10.64898/2026.07.24.740361Read

Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral SclerosisSemantic proximity Read

Spatial enrichment and genomic analyses reveal the link of NOMO1 with amyotrophic lateral sclerosisSemantic proximity Read

Comparative snRNAseq study of C9orf72, SOD1, and sALS spinal cordSemantic proximity Read

Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapesSemantic proximity Read

Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibilitySemantic proximity Read

Gene Expression Signatures of Sporadic ALS Motor Neuron PopulationsSemantic proximity Read

Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibility.Semantic proximity Read

Spatiotemporal Dynamics of Molecular Pathology in Amyotrophic Lateral SclerosisSemantic proximity Read

Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALSSemantic proximity Read

An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALSSemantic proximity Read

Motor System Oligodendroglia Atlas Reveals Activation States Associated with Region-Specific Vulnerability in ALSSemantic proximity Read

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell typesSemantic proximity Read