Article

Modeling motor neuron resilience in ALS using stem cells

2018-08-24

Abstract excerpt

<h4>SUMMARY</h4> Oculomotor neurons, which regulate eye movement, are resilient to degeneration in the lethal motor neuron disease amyotrophic lateral sclerosis (ALS). It would be highly advantageous if motor neuron resilience could be modeled in vitro . Towards this goal, we generated a high proportion of oculomotor neurons from mouse embryonic stem cells through temporal overexpression of Phox2a in neuronal pr...

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Literature Corpus work: 742063fa-2073-50f7-9562-968282c8ce3b
DOI: 10.1101/399659

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