Article

Analyzing ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

2023-11-17

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely limited treatment options. Identification of effective treatments has been limited in part by the lack of predictive animal models for complex age-related human disorders. Here, we utilized pharmacologic ER stressors to exacerbate underlying sensitivities conferred by ALS patient genetics in induced pluripotent stem cell...

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Literature Corpus work: 0dfa3abd-4fb8-5aef-88d1-a984e50e985f
DOI: 10.1101/2023.11.16.567279

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