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Article

Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis.

Neurobiology of disease - 1 Jul 2020

Liu Wenting, Venugopal Sharmila, Majid Sana, Ahn In Sook, Diamante Graciel, Hong Jason, Yang Xia, Chandler Scott H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons throughout the brain and spinal cord progressively degenerate resulting in muscle atrophy, paralysis and death. Recent studies using animal models of ALS implicate multiple cell-types (e.g., astrocytes and microglia) in ALS pathogenesis in the spinal motor systems. To ascertain cellular vulnerability and cell-type specific...

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Identifiers

PMID: 32360664
DOI: 10.1016/j.nbd.2020.104877
PMCID: PMC7519882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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