Article

Divergent mitochondrial and metabolic adaptations shape selective vulnerability in ALS

2026-02-02

Abstract excerpt

Neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) exhibit striking cell-type selectivity, yet the basis for this vulnerability remains elusive. Here, we uncover that even closely related neurons can harbor distinct mitochondrial properties that shape their response to disease. Using TOM-Tag, a circuit-based AAV-based strategy for cell type–specific mitochondrial immunopurification from projection...

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Identifiers and source

Literature Corpus work: 01035ba4-aea5-590b-9537-ec5879086299
DOI: 10.64898/2026.01.30.702552

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