Article

TREM2-H157Y Increases Soluble TREM2 Production and Reduces Amyloid Pathology

2021-10-04

Abstract excerpt

The p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) has been reported to increase Alzheimer’s disease (AD) risk. This mutation in the extracellular domain of TREM2 localizes at the cleavage site, leading to enhanced shedding. Here, we generated a novel Trem2 H157Y knock-in mouse model to investigate how this H157Y mutation impacts TREM2 proteolytic processing, synaptic function, and A...

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Literature Corpus work: 96419c7e-27a8-5a24-af4e-dfc3eb4b7877
DOI: 10.1101/2021.10.04.463020

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