Article

TREM2-H157Y Increases Soluble TREM2 Production and Reduces Amyloid Pathology

2021-10-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: The p.H157Y variant of <italic>TREM2</italic> (Triggering Receptor Expressed on Myeloid Cells 2) has been reported to increase Alzheimer’s disease (AD) risk. This mutation in the extracellular domain of TREM2 localizes at the cleavage site and was shown to enhance shedding and impair phagocytosis <italic>in vitro </italic>by ectopic expression of TREM2-H157Y in...

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Literature Corpus work: 28719fc2-d282-58ef-8c10-d4e5040467b7
DOI: 10.21203/rs.3.rs-960300/v1

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