Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.

Experimental neurology - 1 Oct 2026

Shirotani Keiro, Hatta Daisuke, Watanabe Kaori, Saito Takashi, Saido Takaomi C, Iwata Nobuhisa

Abstract excerpt

The TREM2 R47H variant increases the risk of Alzheimer's disease (AD), yet its functional impact in aged mouse models remains incompletely understood. We generated a humanized Trem2 R47H knock-in (KI) line on the AppNL-F background and compared it with a Trem2 knockout (KO) line to assess the degree of TREM2 functional impairment. Accumulation of amyloid β 42 and formation of dystrophic neurites were increased in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Amyloid beta-Protein Precursor

Share to Gene Knock-In Techniques

Share to Membrane Glycoproteins

Share to Microglia

Share to Receptors, Immunologic

Source

Identifiers

PMID: 42341895
DOI: 10.1016/j.expneurol.2026.115894

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.PMID 42341895Read ↗

<i>Trem2</i> R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to <i>Trem2</i> deficiency in aged <i> App <sup>NL-F</sup> </i> knock-in miceSemantic proximity Read ↗

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.Semantic proximity Read ↗

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.Semantic proximity Read ↗

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.Semantic proximity Read ↗

AD-linked R47H- <i>TREM2</i> mutation induces disease-enhancing proinflammatory microglial states in mice and humansSemantic proximity Read ↗

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.Semantic proximity Read ↗

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.Semantic proximity Read ↗

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.Semantic proximity Read ↗

Sustained TREM2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer disease: The involvement of TREM2 R47H variant in Alzheimer disease confirmed, but mechanisms remain elusive.Semantic proximity Read ↗

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.Semantic proximity Read ↗

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.