Article
The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025
Tsui Jackie Shuk Man, Au Danise M, Uhm Hyebin, Wong Wan-Wa, Lo Ronnie Ming Nok, Jiang Yuanbing, Ip Fanny C F, Mok Kin Y, Wong Hiu Yi, Kwok Timothy C Y, Fu Amy K Y, Ip Nancy Y
Abstract excerpt
INTRODUCTION: Multiple TREM2 variants are associated with an increased risk of Alzheimer's disease (AD). TREM2 H157Y is the only variant located at the proteolytic cleavage site that enhances TREM2 protein shedding. While this variant is associated with increased AD risk predominantly in the Chinese population, its impact on AD pathology is largely unknown. METHODS: We conducted an in-depth study integrating...
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