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Article

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis.

Nature reviews. Neuroscience - 1 Apr 2016

Colonna Marco, Wang Yaming

Abstract excerpt

Genome-wide association studies have identified rare variants of the gene that encodes triggering receptor expressed on myeloid cells 2 (TREM2) - an immune receptor that is found in brain microglia - as risk factors for non-familial Alzheimer disease (AD). Furthermore, animal studies have indicated that microglia have an important role in the brain response to amyloid-β (Aβ) plaques and that TREM2 variants may...

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Identifiers

PMID: 26911435
DOI: 10.1038/nrn.2016.7

Genes

TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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