Article

Sustained TREM2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

2021-06-23

Abstract excerpt

<h4>Summary</h4> TREM2 is a transmembrane protein expressed exclusively in microglia in the brain that regulates inflammatory responses to pathological conditions. Proteolytic cleavage of membrane TREM2 affects microglial function and is associated with Alzheimer’s disease, but the consequence of reduced TREM2 proteolytic cleavage has not been determined. We generated a transgenic mouse model of reduced TREM2 she...

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Literature Corpus work: cc105865-7a67-5230-98af-ca8ddee2c646
DOI: 10.1101/2021.06.23.449405

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