Article
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Molecular neurodegeneration - 1 Jun 2018
Cheng-Hathaway Paul J, Reed-Geaghan Erin G, Jay Taylor R, Casali Brad T, Bemiller Shane M, Puntambekar Shweta S, von Saucken Victoria E, Williams Roxanne Y, Karlo J Colleen, Moutinho Miguel, Xu Guixiang, Ransohoff Richard M, Lamb Bruce T, Landreth Gary E
Abstract excerpt
BACKGROUND: The R47H variant of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) confers greatly increased risk for Alzheimer's disease (AD), reflective of a central role for myeloid cells in neurodegeneration. Understanding how this variant confers AD risk promises to provide important insights into how myeloid cells contribute to AD pathogenesis and progression. METHODS: In order to investigate this...
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