Article
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice.
Molecular neurodegeneration - 28 Oct 2020
Jadhav Vaishnavi S, Lin Peter B C, Pennington Taylor, Di Prisco Gonzalo Viana, Jannu Asha Jacob, Xu Guixiang, Moutinho Miguel, Zhang Jie, Atwood Brady K, Puntambekar Shweta S, Bissel Stephanie J, Oblak Adrian L, Landreth Gary E, Lamb Bruce T
Abstract excerpt
BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including Alzheimer's disease (AD), frontotemporal dementia (FTD) and Nasu Hakola Disease (NHD). The Trem2 variant R47H, confers substantially elevated risk of developing late onset Alzheimer's disease, while NHD-linked Trem2 variants...
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