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Article

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.

The Lancet. Neurology - 1 Aug 2018

Carmona Susana, Zahs Kathleen, Wu Elizabeth, Dakin Kelly, Bras Jose, Guerreiro Rita

Abstract excerpt

Alzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an individual's risk of developing Alzheimer's disease. TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30033062
DOI: 10.1016/S1474-4422(18)30232-1

Genes

TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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