Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

Abstract excerpt

Excessive alcohol consumption poses significant health risks and is closely associated with oxidative damage. The KEAP1-NRF2-ARE signaling pathway serves as the primary antioxidant system. However, current small molecule inhibitors are all covalently bound to KEAP1, meaning that once bound, they are not easily dissociated, while continuous inhibition of KEAP1 exhibits severe side effects. In this study, BLI, CETSA...

Topics

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• Antioxidants
• Cytoskeletal Proteins
• Genomics, phytochemicals, and oxidative stress
• Inactivation, Metabolic
• Kelch-Like ECH-Associated Protein 1
• NF-E2-Related Factor 2
• Oxidative Stress
• Transcriptional Activation

Identifiers and source

Literature Corpus work

96092126-10e7-537e-816d-0d00a425b3bc

DOI

10.1101/2024.01.06.574490