Back to search

Article

Molecular investigation of Keap1-dependent regulation of the Nrf2 cell defence pathway

2014-01-01

Abstract excerpt

Mammalian cells have evolved highly regulated defence pathways, which are activated in response to stress. The transcription factor Nrf2 is activated in response to chemical and oxidative stress and induces the expression of antioxidants and detoxification enzymes. Nrf2 activity is regulated by its cysteine-rich repressor protein Keap1, which facilitates Nrf2 degradation. In the presence of electrophilic compounds...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2a171a12-80fa-5b12-b782-31f107c5b33a
DOI
10.17638/02005540
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular investigation of Keap1-dependent regulation of the Nrf2 cell defence pathwayDOI 10.17638/02005540
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2.Semantic proximity
The Molecular Mechanisms Regulating the KEAP1-NRF2 PathwaySemantic proximity
Nrf2-Keap1 defines a physiologically important stress response mechanism.Semantic proximity
The Keap1–Nrf2 system in cancers: stress response and anabolic metabolismSemantic proximity
Nrf2 as a target for cancer chemoprevention.Semantic proximity
The pharmacological manipulation of the Nrf2 pathway and its therapeutic significanceSemantic proximity
Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.Semantic proximity
Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer.Semantic proximity
Nrf2: bane or blessing in cancer?Semantic proximity
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.Semantic proximity
A systematic analysis of the human Nrf2 networkSemantic proximity
Curcumin activates distinct programming of redox metabolism towards differential regulation of gene expression mediated by Nrf1 and Nrf2Semantic proximity
Select a neighboring publication to make it the new centre.