Nrf2-Keap1 defines a physiologically important stress response mechanism.

doi:10.1016/j.molmed.2004.09.003

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Article

Nrf2-Keap1 defines a physiologically important stress response mechanism.

Trends in molecular medicine - 1 Nov 2004

Motohashi Hozumi, Yamamoto Masayuki

Abstract excerpt

The transcription factor Nrf2 regulates the basal and inducible expression of numerous detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and represses its function. Analysis of keap1-knockout mice provides solid evidence that Keap1 acts as a negative regulator of Nrf2 and as a sensor of xenobiotic and oxidative stresses. The simultaneous ablation of the keap1 and nrf2 genes...

Topics

Adaptor Proteins, Signal Transducing
Animals
Antioxidants
Cytoskeletal Proteins
DNA-Binding Proteins
Gene Expression Regulation
Inactivation, Metabolic
Kelch-Like ECH-Associated Protein 1
Mice
Mice, Knockout
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NF-E2-Related Factor 2

Oxidative Stress

Repressor Proteins

Trans-Activators

Transcriptional Activation

Xenobiotics

Source

Open in PubMed

Identifiers

PMID: 15519281
DOI: 10.1016/j.molmed.2004.09.003

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