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The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

14 Apr 2020

Abstract excerpt

The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by targeting it for ubiquitination and proteasome-dependent degradation. In response to stress, an intricate molecular mechanism facilitated by sensor cysteines within...

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PMID: 32284348
DOI: 10.1128/mcb.00099-20

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