Article

Different inhibition of Nrf2 by two Keap1 isoforms α and β to shape malignant behaviour of human hepatocellular carcinoma

2022-07-15

Abstract excerpt

Nrf2 (nuclear factor E2-related factor 2, encoded by Nfe2l2 ) acts as a master transcriptional regulator in mediating antioxidant, detoxification and cytoprotective responses against oxidative, electrophilic and metabolic stress, but also plays a crucial role in cancer metabolism and multiple oncogenic pathways, whereas the redox sensor Keap1 functions as a predominant inhibitor of Nrf2 and hence changes in its e...

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Literature Corpus work: c5aca2e7-6833-50d0-ae5c-6a4ebc8042f8
DOI: 10.1101/2022.07.15.500244

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