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Article

New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.

Life sciences - 1 Oct 2021

Cheng Liangkai, Wang Huihui, Li Shehan, Liu Zhongqiu, Wang Caiyan

Abstract excerpt

AIMS: Keap1-Nrf2 signaling pathway is one of the most important antioxidant signaling pathways, and its abnormal activation is related to cancer metastasis and drug resistance. Many studies have shown Keap1 and Nrf2 mutations are closely associated with cancer occurrence. However, few studies focus on Keap1-Nrf2 binding characteristics of cancer-associated mutations. The study investigated the molecular mechanism...

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Identifiers

PMID: 34229009
DOI: 10.1016/j.lfs.2021.119791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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