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Article

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer.

Biochemical pharmacology - 1 Jul 2020

Kang Jong-Su, Nam Le Ba, Yoo Ok-Kyung, Keum Young-Sam

Abstract excerpt

NF-E2-related factor 2 (NRF2) is a master regulator of redox homeostasis and provides cellular protection against oxidants and electrophiles by inducing the expression of a wide array of phase II cytoprotective genes. Until now, a number of NRF2 activators have been developed for treatment of chronic diseases and some are under evaluation in the clinical studies. On the other hand, accumulating evidence indicates...

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Identifiers

PMID: 32360363
DOI: 10.1016/j.bcp.2020.114002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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