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Article

Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2.

Pharmacological reviews - 1 Oct 2012

Ma Qiang, He Xiaoqing

Abstract excerpt

Induction of drug-metabolizing enzymes through the antioxidant response element (ARE)-dependent transcription was initially implicated in chemoprevention against cancer by antioxidants. Recent progress in understanding the biology and mechanism of induction revealed a critical role of induction in cellular defense against electrophilic and oxidative stress. Induction is mediated through a novel signaling pathway...

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PMID: 22966037
DOI: 10.1124/pr.110.004333
PMCID: PMC4648289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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