FUNCTIONAL ANALYSIS OF BIPARTITE NRF2 ACTIVATORS THAT OVERCOME FEEDBACK REGULATION FOR AGE-RELATED CHRONIC DISEASES

Abstract excerpt

Activating Nrf2 with small molecules is a promising strategy for countering aging, oxidative stress, inflammation, and various disorders, including neurodegeneration. The primary regulator of Nrf2 protein stability is Keap1, a redox sensor protein and an adapter in the Cullin III ubiquitin ligase complex, which labels Nrf2 for proteasomal degradation. The known Nrf2 activators either chemically modify sensor thiol...

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• Antineoplastic Agents
• Gene Expression Regulation, Neoplastic
• Genomics, phytochemicals, and oxidative stress
• Kelch-Like ECH-Associated Protein 1
• Lung Neoplasms
• Mutation
• Neoplasms
• NF-E2-Related Factor 2

Identifiers and source

Literature Corpus work

83f4fbd7-9b31-5a21-bf14-ec689a7cd81e

DOI

10.1101/2025.05.30.656434