Article

Knockout of Perilipin-2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer’s Disease Stimuli

2025-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Lipid droplets (LDs) are emerging as critical regulators of cellular metabolism and inflammation, with their accumulation in microglia linked to aging and neurodegeneration. Perilipin 2 (Plin2) is a ubiquitously expressed LD-associated protein that stabilizes lipid stores, and in peripheral tissues its upregulation promotes lipid retention, inflammation, and metabolic dysfunction. However, the r...

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Literature Corpus work: 95bcb83a-8a4e-529d-8afc-08826a70023e
DOI: 10.1101/2025.09.02.673815

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