Article

Microglial Perilipin-2 Deficiency Ameliorates Ischemic White Matter Injury via Lipid Metabolic Reprogramming

2026-05-22

Abstract excerpt

<title>Abstract</title> <p> Background Chronic cerebral hypoperfusion-induced white matter lesions are a major contributor to vascular cognitive impairment in aging, characterized by microglial activation and defective clearance of cholesterol-rich myelin debris. Perilipin-2 (PLIN2), a key lipid droplet (LD)-associated protein involved in myelin metabolism, has an undefined role in ischemic white matter injury....

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Literature Corpus work: 03216704-7608-5416-96b2-945fbe4223a3
DOI: 10.21203/rs.3.rs-9688977/v1

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