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Article

Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation.

Cells - 20 Jan 2021

Loving Bailey A, Tang Maoping, Neal Mikaela C, Gorkhali Sachi, Murphy Robert, Eckel Robert H, Bruce Kimberley D

Abstract excerpt

Microglia become increasingly dysfunctional with aging and contribute to the onset of neurodegenerative disease (NDs) through defective phagocytosis, attenuated cholesterol efflux, and excessive secretion of pro-inflammatory cytokines. Dysfunctional microglia also accumulate lipid droplets (LDs); however, the mechanism underlying increased LD load is unknown. We have previously shown that microglia lacking...

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PMID: 33498265
DOI: 10.3390/cells10020198
PMCID: PMC7909280

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