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Article

An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer's brains.

Immunity - 9 Jan 2024

Millet Alon, Ledo Jose Henrique, Tavazoie Sohail F

Abstract excerpt

The dominant risk factors for late-onset Alzheimer's disease (AD) are advanced age and the APOE4 genetic variant. To examine how these factors alter neuroimmune function, we generated an integrative, longitudinal single-cell atlas of brain immune cells in AD model mice bearing the three common human APOE alleles. Transcriptomic and chromatin accessibility analyses identified a reactive microglial population...

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Identifiers

PMID: 38159571
DOI: 10.1016/j.immuni.2023.12.001
PMCID: PMC10805152

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