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Article

Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease.

Nature aging - 1 Oct 2021

Serrano-Pozo Alberto, Li Zhaozhi, Noori Ayush, Nguyen Huong N, Mezlini Aziz, Li Liang, Hudry Eloise, Jackson Rosemary J, Hyman Bradley T, Das Sudeshna

Abstract excerpt

The roles of APOEε4 and APOEε2-the strongest genetic risk and protective factors for Alzheimer's disease-in glial responses remain elusive. We tested the hypothesis that APOE alleles differentially impact glial responses by investigating their effects on the glial transcriptome from elderly control brains with no neuritic amyloid plaques. We identified a cluster of microglial genes that are upregulated in APOEε4...

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Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plaque, Amyloid

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PMID: 36199750
DOI: 10.1038/s43587-021-00123-6
PMCID: PMC9531903

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