Article

MitoScribe single-cell molecular recorder logs graded signaling dynamics into mitochondrial DNA

2025-09-05

Abstract excerpt

<h4>ABSTRACT</h4> Genetically encoded DNA recorders convert transient biological events into stable genomic mutations, offering a means to reconstruct past cellular states. However, current approaches to log historical events by modifying genomic DNA have limited capacity to record the magnitude of biological signals within individual cells. Here, we introduce MitoScribe, a mitochondrial DNA (mtDNA)-based recordi...

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Literature Corpus work: 94af4bef-4785-5642-a89b-5206d8ca8f1d
DOI: 10.1101/2025.09.05.674553

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