Article

Regenerative base editing enables deep lineage recording

2026-02-07

Abstract excerpt

Reconstructing the lineage histories of individual cells can reveal the dynamics of developmental and disease processes. In engineered recording systems, cells stochastically edit synthetic barcode sequences as they proliferate, creating distinct, heritable edit patterns that can be used to reconstruct the lineage trees relating individual cells in a manner analogous to phylogenetic reconstruction. However, record...

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Literature Corpus work: c874240e-f1f9-5ea8-b81e-9d4b63e57f72
DOI: 10.64898/2026.02.06.703857

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