Article

High-resolution retrospective single cell lineage tracing with mutable homopolymers

2026-03-12

Abstract excerpt

Retrospective reconstruction of cell lineages from somatic mutations holds substantial promise for understanding development, tissue homeostasis, and disease. Yet, current approaches are often constrained by low marker density, technical noise, and incomplete molecular readouts that limit the resolution and accuracy of inferred lineages. Here, we present RETrace2, a single-cell dual-omic method for simultaneous li...

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Literature Corpus work: 524d0a83-d167-50e7-a9eb-6cc1a65bb65e
DOI: 10.64898/2026.03.10.709901

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