Article

Reconstructing signaling history of single cells with imaging-based molecular recording

2024-10-12

Abstract excerpt

The intensity and duration of biological signals encode information that allows a few pathways to regulate a wide array of cellular behaviors. Despite the central importance of signaling in biomedical research, our ability to quantify it in individual cells over time remains limited. Here, we introduce INSCRIBE, an approach for reconstructing signaling history in single cells using endpoint fluorescence images. By...

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Literature Corpus work: 51977ef7-4c3c-5dc1-a6e8-afb895bf3c8a
DOI: 10.1101/2024.10.11.617908

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