Article

Epigenetic constraint of cellular genomes evolutionarily links genetic variation to function

2024-10-29

Abstract excerpt

Cellular diversity is a product of evolution acting to drive divergent regulatory programs from a common genome. Here, we use cross-cell-type epigenetic conservation to gain insight into the impact of selective constraints on genome function and phenotypic variation. By comparing chromatin accessibility across hundreds of diverse cell-types, we identify 1.4% of the human genome safeguarded by conserved domains of...

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Literature Corpus work: bd6fb077-4a18-525b-85c3-3c2ed781b182
DOI: 10.1101/2024.10.28.620690

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