Article

Preventing premature deaths through polygenic risk scores

2024-12-29

Abstract excerpt

<h4>Background</h4> Polygenic risk scores (PRS) have demonstrated predictive validity across a range of cohorts and diseases, but quantifying their clinical utility remains a challenge. As PRS can be derived from a single biological sample and remain stable throughout life, we explore the potential of PRS to optimize existing screening programs. <h4>Methods</h4> Via an integrated modelling approach, we quantifie...

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Literature Corpus work: 940dd097-3dfc-54fe-8db9-937a5200b6cc
DOI: 10.1101/2024.12.26.24319670

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