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Article

Developing and evaluating polygenic risk prediction models for stratified disease prevention.

Nature reviews. Genetics - 1 Jul 2016

Chatterjee Nilanjan, Shi Jianxin, García-Closas Montserrat

Abstract excerpt

Knowledge of genetics and its implications for human health is rapidly evolving in accordance with recent events, such as discoveries of large numbers of disease susceptibility loci from genome-wide association studies, the US Supreme Court ruling of the non-patentability of human genes, and the development of a regulatory framework for commercial genetic tests. In anticipation of the increasing relevance of...

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PMID: 27140283
DOI: 10.1038/nrg.2016.27
PMCID: PMC6021129

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