Article
Polygenic Risk Scores Predict Hypertension Onset and Cardiovascular Risk.
Hypertension (Dallas, Tex. : 1979) - 1 Apr 2021
Vaura Felix, Kauko Anni, Suvila Karri, Havulinna Aki S, Mars Nina, Salomaa Veikko, FinnGen, Cheng Susan, Niiranen Teemu
Abstract excerpt
Although genetic risk scores have been used to predict hypertension, their utility in the clinical setting remains uncertain. Our study comprised N=218 792 FinnGen participants (mean age 58 years, 56% women) and N=22 624 well-phenotyped FINRISK participants (mean age 50 years, 53% women). We used public genome-wide association data to compute polygenic risk scores (PRSs) for systolic and diastolic blood pressure...
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