Article
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.
Nature medicine - 1 Apr 2020
Mars Nina, Koskela Jukka T, Ripatti Pietari, Kiiskinen Tuomo T J, Havulinna Aki S, Lindbohm Joni V, Ahola-Olli Ari, Kurki Mitja, Karjalainen Juha, Palta Priit, Neale Benjamin M, Daly Mark, Salomaa Veikko, Palotie Aarno, Widén Elisabeth, Ripatti Samuli
Abstract excerpt
Polygenic risk scores (PRSs) have shown promise in predicting susceptibility to common diseases1-3. We estimated their added value in clinical risk prediction of five common diseases, using large-scale biobank data (FinnGen; n = 135,300) and the FINRISK study with clinical risk factors to test genome-wide PRSs for coronary heart disease, type 2 diabetes, atrial fibrillation, breast cancer and prostate cancer. We...
Topics
- Adult
- Age of Onset
- Biomarkers
- Breast Neoplasms
- Cardiovascular Diseases
- Case-Control Studies
- Diabetes Mellitus, Type 2
- Female
- Finland
- Genetic Markers