Article
Preventing premature deaths through polygenic risk scores.
Nature communications - 21 Jan 2026
Chuong Melisa, Thompson Deborah, Weale Michael E, Riveros-Mckay Fernando, Samani Nilesh J, Wells Daniel, Plagnol Vincent, McVean Gil, Ashley Euan A, Donnelly Peter, Harrison Seamus, O'Sullivan Jack W
Abstract excerpt
Polygenic risk scores (PRS) have demonstrated predictive validity across a range of cohorts and diseases, but quantifying their clinical utility remains a challenge. As PRS can be derived from a single biological sample and remains stable throughout life, we explore the potential of PRS to optimize existing screening programs. Via an integrated modelling approach, we quantify the potential clinical benefits...
Topics
- Humans
- Genetic Risk Score
- Genetic Predisposition to Disease
- Mortality, Premature
- Multifactorial Inheritance
- Male
- Female
- Diabetes Mellitus, Type 2
- Prostatic Neoplasms
- Aortic Aneurysm, Abdominal