A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.

doi:10.1038/s41467-024-48938-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.

Nature communications - 12 Jun 2024

Jermy Bradley, Läll Kristi, Wolford Brooke N, Wang Ying, Zguro Kristina, Cheng Yipeng, Kanai Masahiro, Kanoni Stavroula, Yang Zhiyu, Hartonen Tuomo, Monti Remo, Wanner Julian, Youssef Omar, Lippert Christoph, van Heel David, Okada Yukinori, McCartney Daniel L, Hayward Caroline, Marioni Riccardo E, Furini Simone, Renieri Alessandra, Martin Alicia R, Neale Benjamin M, Hveem Kristian, Mägi Reedik, Palotie Aarno, Heyne Henrike, Mars Nina, Ganna Andrea, Ripatti Samuli

Abstract excerpt

Polygenic scores (PGSs) offer the ability to predict genetic risk for complex diseases across the life course; a key benefit over short-term prediction models. To produce risk estimates relevant to clinical and public health decision-making, it is important to account for varying effects due to age and sex. Here, we develop a novel framework to estimate country-, age-, and sex-specific estimates of cumulative...

Topics

Humans
Male
Female
Multifactorial Inheritance
Incidence
Middle Aged
Genetic Predisposition to Disease
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged

Diabetes Mellitus, Type 2

Risk Factors

Risk Assessment

Global Burden of Disease

Sex Factors

Age Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 38866767
DOI: 10.1038/s41467-024-48938-2
PMCID: PMC11169548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.PMID 38866767Read ↗

A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic riskSemantic proximity Read ↗

A systematic framework for assessing the clinical impact of polygenic risk scoresSemantic proximity Read ↗

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.Semantic proximity Read ↗

Polygenic and clinical risk scores and their impact on age at onset of cardiometabolic diseases and common cancersSemantic proximity Read ↗

Influence and role of polygenic risk score in the development of 32 complex diseasesSemantic proximity Read ↗

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk predictionSemantic proximity Read ↗

Polygenic Risk Scores in Human Disease.Semantic proximity Read ↗

Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction.Semantic proximity Read ↗

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variantsSemantic proximity Read ↗

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction.Semantic proximity Read ↗

<i>PGSFusion</i> streamlines polygenic score construction and epidemiological applications in biobank-scale cohortsSemantic proximity Read ↗

PGS Browser: a public platform for personalized polygenic score analysis and interpretation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.