Article
Identifying and characterizing disease subpopulations that most benefit from polygenic risk scores.
Scientific reports - 27 Sept 2024
Isgut Monica, Giuste Felipe, Gloster Logan, Swain Aniketh, Choi Katherine, Hornback Andrew, Deshpande Shriprasad R, Wang May D
Abstract excerpt
Polygenic risk scores (PRSs) hold promise in their potential translation into clinical settings to improve disease risk prediction. An important consideration in integrating PRSs into clinical settings is to gain an understanding of how to identify which subpopulations of individuals most benefit from PRSs for risk prediction. In this study, using the UK Biobank dataset, we trained logistic regression models to...
Topics
- Humans
- Multifactorial Inheritance
- Genetic Predisposition to Disease
- Female
- Male
- Schizophrenia
- Risk Assessment
- Risk Factors
- Breast Neoplasms
- Myocardial Infarction
- Middle Aged