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Statistical genetics and polygenic risk score for precision medicine

17 Jun 2021

Abstract excerpt

The prediction of disease risks is an essential part of personalized medicine, which includes early disease detection, prevention, and intervention. The polygenic risk score (PRS) has become the standard for quantifying genetic liability in predicting disease risks. PRS utilizes single-nucleotide polymorphisms (SNPs) with genetic risks elucidated by genome-wide association studies (GWASs) and is calculated as...

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PMID: 34140035
DOI: 10.1186/s41232-021-00172-9

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