Article

Multifactorial heterogeneity of the human mutation landscape related to DNA replication dynamics

2022-09-30

Abstract excerpt

Mutations do not occur uniformly across genomes but instead show biased associations with various genomic features, most notably late replication timing. However, it remains contested which mutation types in human cells relate to DNA replication dynamics and to what extents. Previous studies have been limited by the absence of cell-type-specific replication timing profiles and lack of consideration of inter-indivi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cff05f4-9509-5faa-a689-1f8ef166850a
DOI: 10.1101/2022.09.28.509938

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multifactorial heterogeneity of the human mutation landscape related to DNA replication dynamicsDOI 10.1101/2022.09.28.509938Read

Mutational signatures association with replication timing in normal cells reveals similarities and differences with matched cancer tissues.Semantic proximity Read

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate.Semantic proximity Read

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rateSemantic proximity Read

Human mutation rate associated with DNA replication timing.Semantic proximity Read

Cancer Mutational Processes Vary in Their Association with Replication Timing and Chromatin Accessibility.Semantic proximity Read

Complex correlations: replication timing and mutational landscapes during cancer and genome evolution.Semantic proximity Read

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rateSemantic proximity Read

Clock-like mutational signatures: Linking ageing to endogenous cancer risk.Semantic proximity Read

Unveiling Replication Timing-Dependent Mutational Biases: Mechanistic Insights from Gene Knockouts and Genotoxins Exposures.Semantic proximity Read

DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes.Semantic proximity Read

Cancer mutational processes vary in their association with replication timing and chromatin accessibilitySemantic proximity Read

Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution.Semantic proximity Read